Principle-Of-Inheritance-And-Variation Question 667
Question: Which of the following is not a hereditary disease [CBSE PMT 2005]
Options:
A) Cretinism
B) Cystic fibrosis is a genetic disorder that affects the lungs, pancreas, and other organs. It causes thick, sticky mucus to build up in the lungs and obstruct the pancreas, leading to chronic lung infections and digestive problems. The disease is caused by mutations in the CFTR gene, which regulates the movement of salt and water in and out of cells. Cystic fibrosis is inherited in an autosomal recessive pattern, meaning a person must inherit two defective copies of the CFTR gene, one from each parent, to have the disease. There is no cure, but treatments can help manage symptoms and improve quality of life.
C) Thalassaemia (also known as Mediterranean anaemia) is a group of inherited blood disorders characterised by reduced haemoglobin synthesis, leading to chronic anaemia. It is caused by mutations in the genes that encode the beta-globin chains of haemoglobin, most commonly the HBB gene. The severity of the condition varies depending on the specific mutation and the number of affected genes. Thalassaemia is most common in populations of Mediterranean, Middle Eastern, and South Asian descent.
D) Haemophilia
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Answer:
Correct Answer: A
Solution:
Cystic fibrosis, Thalassaemia and haemophilia are hereditary diseases.
BETA
