Biomolecules Question 180

Question: The $ pK_4 $ values for the three ionizable groups X, Y and Z of glutamic acid are 4.3, 9.7 and 2.2 respectively $ \underset{X}{\mathop{HO_2C}}-CH_2-\underset{Y}{\mathop{\underset{ _{+}NH_3}{\mathop{\underset{|}{\mathop{C}}}}H}}-\underset{Z}{\mathop{CO_2H}} $ The isoelectric point for the amino acid is:

Options:

A) 7.00

B) 3.25

C) 4.95

D) 5.95

Show Answer

Answer:

Correct Answer: B

Solution:

[b] In acidic medium $ \frac{4.3+2.2}{2}~=3.25 $