Carboxylic Acids Question 6

Question: Which is most reactive of the following

[J & K 2005]

Options:

A) Ethyl acetate

B) Acetic anhydride

C) Acetamide

D) Acetyl chloride

Show Answer

Answer:

Correct Answer: D

Solution:

The order of reactivity of acid derivatives towards different reactions decreases in the order, $ RCOCl>{{(RCO)}_2}O>RCOO{R}’>RCONH_2 $ In other words, the reactivity decreases as the basicity of the leaving group increases i.e., $ C{l^{-}}<RCO{O^{-}}<R{O^{-}}<NH_2^{-} $