Biotechnology-And-Its-Application-Part-2

Transgenic Animals:

• Transgenic animals have foreign genes introduced into their genome through genetic engineering.

• They are used in scientific research to study gene function, model diseases, and develop therapies.

• Foreign genes are integrated into their DNA to investigate specific gene effects.

Understanding Disease Mechanism:

• Understanding disease mechanisms is crucial in biomedical research.

• It involves studying processes and factors contributing to disease development and progression.

• Transgenic animals are used to gain insights into disease mechanisms for effective treatments.

(AIDS) Model:

• Transgenic mice are used to study AIDS (Acquired Immunodeficiency Syndrome).

• Genes related to HIV infection are introduced to mimic disease progression.

• These models help test potential therapies and vaccines.

Alzheimer Mouse:

• Transgenic mice model Alzheimer’s disease.

• They express genes associated with Alzheimer’s.

• Used to study disease pathogenesis, develop treatments, and test drugs.

Transgenic Models for Diabetes:

• Transgenic animals, especially mice, are used to study diabetes.

• Genes related to diabetes susceptibility or insulin production are introduced.

• Helps investigate disease mechanisms and treatment development.

Transgenic Animals for Organ Transplantation:

• Transgenic pigs are developed for xenotransplantation (organ transplantation).

• Pig organs are modified to be more compatible with humans.

• Aims to address the shortage of human donor organs.

Transgenesis: Step-03 - Selection and Screening:

• Selection and screening follow the introduction of foreign DNA into the host organism.

• Identify and confirm the presence of the desired gene in transgenic animals.

• Ensures that only animals with the intended genetic modification are used for further research or breeding.