Biomolecules Ques 53
53. The two polypeptides of human insulin are linked together by
[2016]
(a) hydrogen bonds
(b) phosphodiester bond
(c) covalent bond
(d) disulphide bridges
Show Answer
Answer : d
Hints & Solutions
(d) Insulin is a hormone consisting of 2 polypeptide chains. Each chain is composed of a specific sequence of amino acid residues connected by peptide bonds. In humans, chain A has 21 amino acids, and chain $B$ has 30 . Post translational modifications result in the connection of these two chains by disulfide bridges.
[Image]
Cysteine residues on A7 and B7, as well as A20 to B19 are covalently connected by disulfide bridges.
BETA
