Biomolecules and Chemistry in Everyday Life - Result Question 15
16. The predominant form of histamine present in human blood is $\left(p K _a\right.$, Histidine $\left.=6.0\right)$
(2018 Main)
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Answer:
Correct Answer: 16. (d)
Solution:
- Our blood is slightly basic in nature with $pH$ range from $7.35-7.4$. The structure of histamine is given below :
It is produced by decarboxylation of histidine having following structure. It is clearly visible from the above structure that histamine has two basic centres namely aliphatic amino group and basic nitrogen of imidazole ring. The aliphatic amino group has $p K _a$ around $9.4$. In blood with $pH$ around $7.4$ the aliphatic amino group of histamine become protonated to give a single charged cation as shown below
BETA
